Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments. Having undergone and completed an extensive renovation and reopening in 2017, the Main Street Inn B&B’s proprietors, Susan O’Donnell and Patrick Fahey would like to welcome you to what we hope will be a truly wonderful, relaxing and memorable experience.
The Main Street Inn B&B has ten rooms, each with a distinctive design, private baths, eco-friendly toiletries, hair dryers, irons, fine linens, seating areas and complimentary WiFi. We are also pleased to offer a pet-friendly room, located on the street level with a private side entry, for those individuals who love to travel with their faithful companions.
A full Breakfast is served every morning between 8:00 am and 10:00 am and coffee is available on all floors 24 hours a day.
Each evening of your stay, you are invited to attend a simple wine reception from 5:00pm to 7:00pm in the North Parlor.
Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.
Perched on the west bank of the Mississippi River, the village of Ste. Genevieve was settled in the late 1740’s about two miles south of its present location.
Local wineries uncorked their new vintages in Ste. Genevieve county with a flourish at four new facilities in 2003.
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