Main Street Inn B&B

Saint Genevieve, Missouri

Main Street Inn B&B

Saint Genevieve, Missouri

Main Street Inn B&B

Saint Genevieve, Missouri

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A Historic Bed & Breakfast Built in 1882


Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments. Having undergone and completed an extensive renovation and reopening in 2017, the Main Street Inn B&B’s proprietors, Susan O’Donnell and Patrick Fahey would like to welcome you to what we hope will be a truly wonderful, relaxing and memorable experience.

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Stay With Us


The Main Street Inn B&B has ten rooms, each with a distinctive design, private baths, eco-friendly toiletries, hair dryers, irons, fine linens, seating areas and complimentary WiFi. We are also pleased to offer a pet-friendly room, located on the street level with a private side entry, for those individuals who love to travel with their faithful companions.

A full Breakfast is served every morning between 8:00 am and 10:00 am and coffee is available on all floors 24 hours a day.

Each evening of your stay, you are invited to attend a simple wine reception from 5:00pm to 7:00pm in the North Parlor.

During Your Stay


Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.

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Annual Events

Learn of all the local events St. Genevieve has to offer year round.

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Saint Genevieve

Perched on the west bank of the Mississippi River, the village of Ste. Genevieve was settled in the late 1740’s about two miles south of its present location.

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Wineries Nearby

Local wineries uncorked their new vintages in Ste. Genevieve county with a flourish at four new facilities in 2003. 

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